abstract：BACKGROUND:In Switzerland, intravenous drug use accounts for the majority of hepatitis C virus (HCV) infections. Early HCV treatment prevents further transmissions and reduces morbidity and mortality due to decompensated liver cirrhosis and hepatocellular carcinoma. Nevertheless, patients in drug substitution programme...

journal_title：Swiss medical weekly

authors： Bregenzer A,Conen A,Knuchel J,Friedl A,Eigenmann F,Näf M,Ackle P,Roth M,Fux CA

更新日期：2017-11-20 00:00:00

abstract：AIMS OF THE STUDY:Premature discontinuation occurs in about 25% of randomised clinical trials in Switzerland; it mainly affects investigator-initiated trials and is mostly due to problems with recruitment of patients. The aim of this study was to qualitatively investigate reasons for trial discontinuation due to poor p...

journal_title：Swiss medical weekly

authors： Briel M,Elger B,von Elm E,Satalkar P

更新日期：2017-11-16 00:00:00

abstract：QUESTION UNDER STUDY:Switzerland has been receiving migrants of various origins for more than 50 years. The adoption of risk-taking behaviours among migrant youths is unclear. Moreover, when studied, migrant youths are rarely analysed according to whether they are first or second generation, or just young people with m...

journal_title：Swiss medical weekly

authors： Campisi L,Berchtold A,Barrense-Dias Y,Akre C,Gehri M,Suris JC

更新日期：2017-11-08 00:00:00

abstract：:Multicentric carpotarsal osteolysis (MCTO) is an autosomal dominant disease of the skeleton characterised by progressive destruction of carpal and tarsal bones. Recently, it has been demonstrated that this disease is caused by heterozygous mutations in the gene for the transcriptional repressor MAFB. We analysed genom...

journal_title：Swiss medical weekly

authors： Zhuang L,Adler S,Aeberli D,Villiger PM,Trueb B

更新日期：2017-10-27 00:00:00

abstract：:Understanding how best to manage the complex healthcare needs of hospitalised, mostly multimorbid medical patients is an international priority. Healthcare should be effective, safe and provide high quality at a reasonable cost. However, basic logistic and organisational issues of medical ward-based care have received...

journal_title：Swiss medical weekly

authors： Kutz A,Ebrahimi F,Struja T,Greenwald J,Schuetz P,Mueller B

更新日期：2017-10-22 00:00:00

abstract：PURPOSE:Staphylococcus aureus bloodstream infections (SA BSI) are associated with substantial mortality. The rapid emergence of methicillin-resistant S. aureus (MRSA), known to be associated with worse outcome, may blur advances made regarding mortality attributed to SA BSI caused by methicillin-sensitive S. aureus (MS...

journal_title：Swiss medical weekly

authors： Wiggli BJ,Frei R,Laffer R,Tschudin Sutter S,Widmer AF

更新日期：2017-09-30 00:00:00

abstract：:Antiosteoporotic drugs are recommended in patients with fragility fractures and in patients considered to be at high fracture risk on the basis of clinical risk factors and/or low bone mineral density. As first-line treatment most patients are started with an antiresorptive treatment, i.e. drugs that inhibit osteoclas...

journal_title：Swiss medical weekly

authors： Meier C,Uebelhart B,Aubry-Rozier B,Birkhäuser M,Bischoff-Ferrari HA,Frey D,Kressig RW,Lamy O,Lippuner K,Stute P,Suhm N,Ferrari S

更新日期：2017-08-16 00:00:00

abstract：:The anti-inflammatory genes, haem oxygenase 1 (HO-1, HMOX1) rs2071746 (unrestricted model: p = 9.07 × 10-4; recessive model: p = 4.99 × 10-4; multiplicative model: p = 0.0009; and additive model: p = 1.87 × 10-4) and interleukin-10 (IL-10) rs1800872 (dominant model: p = 0.0277) have been associated with paediatric inf...

journal_title：Swiss medical weekly

authors： Lin Z,Hao H,Hegarty JP,Lin TR,Wang Y,Harris LR,Xu HN,Wu R,Thomas NJ,Floros J

更新日期：2017-08-02 00:00:00

abstract：:Beta-haemolytic streptococci of groups C and G have become increasingly recognized as causes of invasive human infections. We reviewed clinical and molecular characteristics of Streptococcus dysgalactiae isolates that caused bacteraemia in adults from 2006 to 2015. Among 67 episodes, skin and soft-tissue infections (4...

journal_title：Swiss medical weekly

authors： Ruppen C,Rasmussen M,Casanova C,Sendi P

更新日期：2017-07-24 00:00:00

abstract：OBJECTIVE:Coronary artery bypass grafting (CABG) remains the gold standard for complex revascularisation in multivessel disease. The concept of the minimally invasive extracorporeal circulation circuit (MiECC) was introduced to minimise pathophysiological side effects of conventional extracorporeal circulation. This st...

journal_title：Swiss medical weekly

authors： Winkler B,Heinisch PP,Zuk G,Zuk K,Gahl B,Jenni HJ,Kadner A,Huber C,Carrel T

更新日期：2017-07-10 00:00:00

abstract：PURPOSE:Sayana® was introduced as the first depot medroxyprogesterone acetate-containing contraceptive that is administered via subcutaneous injection. Within 10 months, the Regional Pharmacovigilance Centre (RPVC) Zurich received several anonymous reports of serious local reactions after Sayana® administration. In thi...

journal_title：Swiss medical weekly

authors： Jödicke AM,Dahmke H,Damke B,Schäublin M,Kullak-Ublick GA,Weiler S

更新日期：2017-05-10 00:00:00

abstract：BACKGROUND:Based on a reduction in morbidity and mortality, cardiac resynchronisation therapy (CRT) has evolved as a standard therapy for patients with advanced heart failure. OBJECTIVE:To provide insight into patient demographics, safety, echocardiographic remodelling and long-term follow-up of patients treated with ...

journal_title：Swiss medical weekly

authors： Winnik S,Elsener C,Seifert B,Starck C,Straub A,Saguner AM,Breitenstein A,Krasniqi N,Wilhelm MJ,Haegeli L,Duru F,Benussi S,Maisano F,Lüscher TF,Holzmeister J,Huerlimann D,Ruschitzka F,Steffel J

更新日期：2017-04-18 00:00:00

abstract：BACKGROUND:Extracorporeal photopheresis (ECP) has been reported to be safe and the ultimate treatment option in lung transplant recipients with chronic lung allograft dysfunction (CLAD), the main overall cause of mortality in lung transplant recipients. However, ECP is not reimbursed in selected health jurisdictions, a...

journal_title：Swiss medical weekly

authors： Robinson CA,Huber L,Murer C,Schuurmans M,Kohler M,Hofbauer G,Benden C

更新日期：2017-03-13 00:00:00

abstract：QUESTIONS UNDER STUDY:Teenage and young adult (TYA) cancer patients are faced with the diagnosis during a challenging period of psychosocial development that may affect social outcomes in the long term. Therefore, we aimed to: (1) determine differences in social outcomes between long-term TYA cancer survivors and healt...

journal_title：Swiss medical weekly

authors： Mader L,Vetsch J,Christen S,Baenziger J,Roser K,Dehler S,Michel G

更新日期：2017-03-07 00:00:00

abstract：BACKGROUND:Organs donated for transplantation remain a scarce resource in Switzerland. One of the reasons for this situation is the high percentage of patients or families who refuse to consent to donation. This study aimed to provide an overview of attitudes towards organ donation among Swiss residents, including any ...

journal_title：Swiss medical weekly

authors： Weiss J,Shaw D,Schober R,Abati V,Immer FF,Comité National du Don d'Organes Cndo

更新日期：2017-02-03 00:00:00

abstract：PRINCIPLES:Neuroendocrine neoplasms (NENs) are believed to be associated with an increased risk for additional malignancies (AMs). We aimed to (1) assess the occurrence of AM in NEN patients (2) investigate the characteristics and temporal relationship of NEN patients with and without AM. METHODS:The SwissNET registry...

journal_title：Swiss medical weekly

authors： Kollár A,Blank A,Perren A,Bütikofer L,Stettler C,Christ E

更新日期：2016-11-12 00:00:00

abstract：AIMS:We aimed to identify familial hypercholesterolaemia mutation carriers among participants to the Lausanne Institutional Biobank (BIL). Our experimental workflow was designed as a proof-of-concept demonstration of the resources and services provided by our integrated institutional clinical research support platform....

journal_title：Swiss medical weekly

authors： Maurer F,Pradervand S,Guilleret I,Nanchen D,Maghraoui A,Chapatte L,Bojkowska K,Bhuiyan ZA,Jacquemont N,Harshman K,Mooser V

更新日期：2016-08-06 00:00:00

abstract：QUESTIONS UNDER STUDY:Lung cancer belongs to the most common cancers in Switzerland. We examined trends in lung cancer incidence, with focus on sex, histology and laterality, in the Canton of Zurich since 1980. MATERIAL AND METHODS:Registry data consisting of 16 798 lung cancer cases from 1980 to 2010 were analysed. C...

journal_title：Swiss medical weekly

authors： Oberli LS,Valeri F,Korol D,Rohrmann S,Dehler S

更新日期：2016-07-11 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a vascular disease of unknown aetiology, characterised by an abnormal thickening of the arterial wall that is responsible for an increase in pulmonary vascular resistance. The haemodynamic consequence of PAH is an increased afterload for the right ventricle and, eventually, rig...

journal_title：Swiss medical weekly

authors： Yerly P,Prella M,Aubert JD

更新日期：2016-05-31 00:00:00

abstract：:Patients with chronic heart failure who are not eligible for heart transplant and whose life expectancy depends mainly on the heart disease may benefit from mechanical circulatory support. Mechanical circulatory support restores adequate cardiac output and organ perfusion and eventually improves patients' clinical con...

journal_title：Swiss medical weekly

authors： Tozzi P,Hullin R

更新日期：2016-03-05 00:00:00

abstract：PRINCIPLES:Analysis of the spatial distribution of mortality data is important for identification of high-risk areas, which in turn might guide prevention, and modify behaviour and health resources allocation. This study aimed to update the Swiss mortality atlas by analysing recent data using Bayesian statistical metho...

journal_title：Swiss medical weekly

authors： Chammartin F,Probst-Hensch N,Utzinger J,Vounatsou P

更新日期：2016-02-22 00:00:00

abstract：OBJECTIVE:To assess the presence of Mycoplasma pneumoniae-associated encephalitis in children in Switzerland and its likely pathogenesis. METHODS:M. pneumoniae-associated encephalitis cases seen at a single-centre during 2010-2013 were reviewed, and the Swiss Paediatric Surveillance Unit (SPSU) prospectively conducted...

journal_title：Swiss medical weekly

authors： Meyer Sauteur PM,Moeller A,Relly C,Berger C,Plecko B,Nadal D,Swiss Pediatric Surveillance Unit (SPSU).

更新日期：2016-01-11 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder and the most common cause for dementia, which affects approximately 120 thousand people in Switzerland and 35 million worldwide. Aging is a major risk factor for developing AD and thus, as our societies are growing older, we face great challenges to find treatme...

journal_title：Swiss medical weekly

authors： Konietzko U

更新日期：2015-12-23 00:00:00

abstract：BACKGROUND:Many antimicrobial stewardship programmes (ASPs) target the intensive care unit owing to high antimicrobial utilisation. In this review, we summarise and assess the quality of evidence supporting the implementation of various ASP strategies in the intensive care unit setting with a focus on publications betw...

journal_title：Swiss medical weekly

authors： Mertz D,Brooks A,Irfan N,Sung M

更新日期：2015-12-21 00:00:00

abstract：BACKGROUND:In Switzerland, patients may undergo "blood tests" without being informed what these are screening for. Inadequate doctor-patient communication may result in patient misunderstanding. We examined what patients in the emergency department (ED) believed they had been screened for and explored their attitudes t...

journal_title：Swiss medical weekly

authors： Favre-Bulle T,Baudat D,Darling KE,Mamin R,Peters S,Cavassini M,Hugli O

更新日期：2015-12-04 00:00:00

abstract：QUESTIONS UNDER STUDY:Optimal oxygen saturation (SpO2) targets for extremely low gestational age neonates (ELGANs, gestational age [GA] <28 weeks) are unknown. Conflicting results from five recently published multicentre trials, which randomised ELGANs to high (91 to 95%) or low (85 to 89%) SpO2 targets from birth up t...

journal_title：Swiss medical weekly

authors： Hergenhan A,Steurer M,Berger TM

更新日期：2015-11-02 00:00:00

abstract：:The humble house mouse has long been a workhorse model system in biomedical research. The technology for introducing site-specific genome modifications led to Nobel Prizes for its pioneers and opened a new era of mouse genetics. However, this technology was very time-consuming and technically demanding. As a result, m...

journal_title：Swiss medical weekly

authors： Kaczmarczyk L,Jackson WS

更新日期：2015-10-29 00:00:00

abstract：QUESTION UNDER STUDY:What are the trends in avoidable cancer mortality in Switzerland and neighbouring countries? METHODS:Mortality data and population estimates 1996-2010 were obtained from the Swiss Federal Statistical Office for Switzerland and the World Health Organization Mortality Database (http://www.who.int/he...

journal_title：Swiss medical weekly

authors： Feller A,Mark MT,Steiner A,Clough-Gorr KM

更新日期：2015-10-02 00:00:00

abstract：:Since 2010, awareness of the global threat caused by antimicrobial resistance (AMR) has risen considerably and multiple policy and research initiatives have been implemented. Research and development (R&D) of much-needed new antibiotics active against multiresistant pathogens is a key component of all programmes aimin...

journal_title：Swiss medical weekly

authors： Bettiol E,Harbarth S

更新日期：2015-07-31 00:00:00

abstract：BACKGROUND:The number of individuals with autoimmune inflammatory rheumatic diseases (AIIRDs) treated with immunosuppressive drugs is increasing steadily. The variety of immunosuppressive drugs and, in particular, biological therapies is also rising. The immunosuppressants, as well as the AIIRD itself, increase the ris...

journal_title：Swiss medical weekly

authors： Bühler S,Eperon G,Ribi C,Kyburz D,van Gompel F,Visser LG,Siegrist CA,Hatz C

更新日期：2015-07-28 00:00:00

abstract：:Each year, over 5 million people die worldwide from stroke, and at least every sixth patient who survives will experience another stroke within five years [1]. We are therefore eager to advance early and rapid diagnosis, prognosis and optimal risk stratification, as well as secondary prevention. In this context, blood...

journal_title：Swiss medical weekly

authors： Sonderer J,Katan Kahles M

更新日期：2015-05-29 00:00:00

abstract：QUESTIONS UNDER STUDY:In this work we wanted to evaluate the effect of intra-articular injection (IAI) at the knee joint of 1 ml of Diprospan on the hypothalamic-pituitary-adrenal (HPA) axis. METHODS:Consecutive patients attending the rheumatology or orthopaedic clinic with osteoarthritic knee pain not responding sati...

journal_title：Swiss medical weekly

authors： Habib G,Zahran R,Najjar R,Badarny S,Jabbour A,Artul S,Hakim G,Jabaly-Habib H

更新日期：2015-05-21 00:00:00

abstract：:The current situation of the biomedical sciences is critically discussed. It can be summarized as follows: 1. We have to acknowledge the presence of a serious credibility problem, which might undermine the foundations of medical science. ("Sliding on a slippery slope") 2. Multiple forces going beyond simple conflicts ...

journal_title：Swiss medical weekly

authors： Obrist R

更新日期：2015-03-13 00:00:00

abstract：PRINCIPLES:We aimed to evaluate the efficacy of, and treatment satisfaction with, insulin glargine administered with SoloSTAR® or ClikSTAR® pens in patients with type 2 diabetes mellitus managed by primary care physicians in Switzerland. METHODS:A total of 327 patients with inadequately controlled type 2 diabetes were...

journal_title：Swiss medical weekly

authors： Riebenfeld D,Spirk D,Mathis A,Villiger L,Gerber PA,Gasser UE,Lehmann R

更新日期：2015-03-05 00:00:00

abstract：PURPOSE:There is increasing pressure on general practitioners (GPs) to identify patients with abdominal obesity in order to reduce the life-threatening consequences of this condition in the population. We aimed to confirm previous findings on the inaccuracy of anthropometric measurements performed by GPs in an academic...

journal_title：Swiss medical weekly

authors： Sebo P,Haller D,Pechère-Bertschi A,Bovier P,Herrmann F

更新日期：2015-02-21 00:00:00

abstract：OBJECTIVE:Regular checking of the fitness to drive of elderly car-license holders is required in some countries, and this will become increasingly important as more countries face aging populations. The present study investigated whether the analysis of saccadic eye movements could be used as a screening method for the...

journal_title：Swiss medical weekly

authors： Schmitt KU,Seeger R,Fischer H,Lanz C,Muser M,Walz F,Schwarz U

更新日期：2015-02-09 00:00:00

abstract：:The antineutrophil cytoplasmic antibody (ANCA) associated vasculitides (AAV) are a group of primary vasculitides that affect predominantly small- to medium-sized blood vessels. AAV include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA). D...

journal_title：Swiss medical weekly

authors： Daikeler T,Kistler AD,Martin PY,Vogt B,Huynh-Do U

更新日期：2015-02-06 00:00:00

abstract：INTRODUCTION:Data suggest that a substantial proportion of psychotherapists engage in therapist-client sex (TCS), violating national and international ethical guidelines. The objective of our study was to find a new and effective starting point for preventive interventions. METHOD:Using an online questionnaire, this s...

journal_title：Swiss medical weekly

authors： Hollwich S,Franke I,Riecher-Rössler A,Reiter-Theil S

更新日期：2015-02-04 00:00:00

abstract：OBJECTIVE:The first description of the simplified acute physiology score (SAPS) II dates back to 1993, but little is known about its accuracy in daily practice. Our purpose was to evaluate the accuracy of scoring and the factors that affect it in a nationwide survey. METHODS:Twenty clinical scenarios, covering a broad...

journal_title：Swiss medical weekly

authors： Previsdomini M,Cerutti B,Merlani P,Kaufmann M,van Gessel E,Rothen HU,Perren A

更新日期：2014-12-23 00:00:00

abstract：OBJECTIVE:To assess outcomes 24 months after treatment start for multidrug-resistant tuberculosis (MDR-TB). METHODS:Cohort study of all culture-positive MDR-TB cases notified in Switzerland from 01/2003 to 07/2010. RESULTS:Fifty-one cases were observed, with a median age of 26 years (range 2-56). Twenty-seven were ma...

journal_title：Swiss medical weekly

authors： Helbling P,Altpeter E,Egger JM,Zellweger JP

更新日期：2014-12-04 00:00:00